One page web apps and inline javascript and CSS

We've built what is called a one page web app(a single html page + ajax) In the pursuit of shaving as much http calls as possible, we bundled the JS and CSS in 2 files. Meanwhile we took a look at the way Google Buzz for mobile is built and there are some interesting points: - inline SCRIPT and STYLE - no external JS and CSS - data:images in CSS instead of url(...) Thus we went further and "inlined" the 2 JS and CSS files in SCRIPT and STYLE tags. Removing 2 precious http calls. Anyone experienced some troubles doing that on desktop browsers ? I'm not trying to open a religious debate about unobtrusivity ;) It is about performance, network latency, mobile pages, etc...